反应详情

To a solution of 4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butyric acid methyl ester (900 mg) in methanol (10 ml) was added 2N sodium hydroxide (3 ml) under ice-cooling and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated, and the residue was dissolved in water and washed with ether. The aqueous layer was adjusted to pH 5 with 1N hydrochloric acid, and concentrated to dryness. Chloroform was added to the residue and the insoluble materials were filtered off. The filtrate was concentrated to give 850 mg of 4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butyric acid.

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated
3. dissolutionthe residue was dissolved in water
4. washwashed with ether
5. concentrationconcentrated to dryness
6. additionChloroform was added to the residue
7. filtrationthe insoluble materials were filtered off
8. concentrationThe filtrate was concentrated