Sodium Hydroxide → 4-Oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butyric acid

Participants

Reaction Steps

To a solution of 4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butyric acid methyl ester (900 mg) in methanol (10 ml) was added 2N sodium hydroxide (3 ml) under ice-cooling and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated, and the residue was dissolved in water and washed with ether. The aqueous layer was adjusted to pH 5 with 1N hydrochloric acid, and concentrated to dryness. Chloroform was added to the residue and the insoluble materials were filtered off. The filtrate was concentrated to give 850 mg of 4-oxo-4-[3-(2-oxo-1-pyrrolidinyl)propylamino]butyric acid.

Provenance & Evidence