反应详情

N,N'-Carbonyldiimidazole (9.79 g) was added to a solution of 3,4-dimethoxybenzoic acid (10.0 g) in THF (300 ml) and the whole was stirred for 30 mins. at room o temperature. Then, following by addition of 3-amino-ε-caprolactam (7.04 g), the mixture was stirred for 5 hrs. The resultant precipitate was collected by filtration, washed and dried under reduced pressure to give the title compound (8.5 g). This product used in the following reaction without purification. m.p. 190°-191°.

1. stirringthe mixture was stirred for 5 hrs
2. filtrationThe resultant precipitate was collected by filtration
3. washwashed
4. customdried under reduced pressure