Hydrochloric Acid → HCID 19090437, compound

HRID 892624Notes

Reaction equation

HRID 892624 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][C:12]1[S:13][C:14]2[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]=2[N:21]=1)=O)(C)(C)C>CO>[ClH:1].[ClH:1].[NH2:9][CH2:10][CH2:11][C:12]1[S:13][C:14]2[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]=2[N:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15069547HCID 15069547, compound

Product 1

HCID 19090437HCID 19090437, compoundYield 70.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution (3 ml) of 4.75N hydrochloric acid in methanol was added to a solution (10 ml) of 2-[2-(tert-butoxycarbonylamino)ethyl]-5,6,7,8-tetrahydro-4H-thiazolo-[5,4-b]azepine (1.00 g) in methanol, and the whole was stirred for 5 hrs. at room temperature. The solvent was distilled off under reduced pressure. The residue was washed with ethyl ether, and recrystallized from a mixture of methanol and ethyl ether to give the title compound (0.64 g, 70.5%).

Workup

  1. customat room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. washThe residue was washed with ethyl ether
  4. customrecrystallized from a mixture of methanol and ethyl ether

Sources & evidence

ORD record
ord-0eaaf0c1bf5a455981978f73daacb639
Source dataset
uspto-grants-1992_06
Patent number
US05118806

Reaction notes

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