Dichloromethane → 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(piperidin-4-yl)benzamide
Reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([c:16]2[cH:17][c:18]([O:43][CH3:44])[c:19]([NH:22][c:23]3[n:24][cH:25][c:26]4[c:27]([n:42]3)[N:28]([CH:37]3[CH2:38][CH2:39][CH2:40][CH2:41]3)[CH2:29][C:30]([F:35])([F:36])[C:31](=[O:34])[N:32]4[CH3:33])[cH:20][cH:21]2)=[O:45])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:53][CH2:54][Cl:55].[OH:46][C:47]([C:48]([F:49])([F:50])[F:51])=[O:52]>>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([c:16]2[cH:17][c:18]([O:43][CH3:44])[c:19]([NH:22][c:23]3[n:24][cH:25][c:26]4[c:27]([n:42]3)[N:28]([CH:37]3[CH2:38][CH2:39][CH2:40][CH2:41]3)[CH2:29][C:30]([F:35])([F:36])[C:31](=[O:34])[N:32]4[CH3:33])[cH:20][cH:21]2)=[O:45])[CH2:12][CH2:13]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-c81f22b21d834126a67aec2b5bd0353a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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