反应详情

A mixture of the 1-(3-fluorobenzoyl)-4-ethyl semicarbazide and 1N NaOH solution (100 mL) was refluxed for 20 hr, cooled to room temperature and neutrallized with conc. HCl. The suspension was extracted with ethyl acetate and the organic layer was dried over MgSO4. Removal of the solvent in vacuo yielded 7.3 g of 3-(3-fluorophenyl)-4-ethyl-1,2,4-triazolin-5-one as a white solid. mp 135°-140° C.

1. temperaturewas refluxed for 20 hr
2. extractionThe suspension was extracted with ethyl acetate
3. dry with materialthe organic layer was dried over MgSO4
4. customRemoval of the solvent in vacuo