Hydrochloric Acid → HCID 15157733, compound

Participants

Reaction Steps

To a solution of ethyl 5,6-dihydro-1,2-dioxo-4H-pyrrolo[3,2,1-ij]quinolin-8-ylacetate (21.5 g) and sodium hydroxide (18.5 g) in water (1 litter) was added 35% hydrogen peroxide solution (10 ml) and stirred for 3 hours at room temperature. The mixture was acidified at pH 2 with concentrated hydrochloric acid, resulting precipitate was collected by filtration, washed with water and dried to yield 17.6 g (95.1%) of the title compound. The compound was recrystallized from ethanol to give pale yellow needles, mp 210°-211° C.

Provenance & Evidence