Hydrochloric Acid → HCID 15157733, compound

HRID 892737Notes

Reaction equation

HRID 892737 reaction equation
[O:1]=[C:2]1[C:12]2=[C:13]3[C:8](=[CH:9][C:10]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:11]2)[CH2:7][CH2:6][CH2:5][N:4]3C1=O.[OH-:21].[Na+].OO.Cl>O>[C:2]([C:12]1[CH:11]=[C:10]([CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[C:8]2[C:13]=1[NH:4][CH2:5][CH2:6][CH2:7]2)([OH:1])=[O:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 15157732HCID 15157732, compound

Product 1

HCID 15157733HCID 15157733, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of ethyl 5,6-dihydro-1,2-dioxo-4H-pyrrolo[3,2,1-ij]quinolin-8-ylacetate (21.5 g) and sodium hydroxide (18.5 g) in water (1 litter) was added 35% hydrogen peroxide solution (10 ml) and stirred for 3 hours at room temperature. The mixture was acidified at pH 2 with concentrated hydrochloric acid, resulting precipitate was collected by filtration, washed with water and dried to yield 17.6 g (95.1%) of the title compound. The compound was recrystallized from ethanol to give pale yellow needles, mp 210°-211° C.

Workup

  1. customresulting precipitate
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-9a3f57ec1d81427bb980e5cdd3ec0eb6
Source dataset
uspto-grants-1992_06
Patent number
US05120743

Reaction notes

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