HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → [R]-(-)-2-(p-fluorophenyl)-3-methylbutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (2R)-2-(4-fluorophenyl)-3-methylbutanoic acid | HCID 10888841 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [R]-(-)-2-(p-fluorophenyl)-3-methylbutyryl chloride | HCID 53636491 | — |
Reaction Steps
A solution of 32.3 g (0.165 mol) of [R]-(-)-2-(p-fluorophenyl)-3-methylbutyric acid in 250 ml of abs. methylene chloride was treated with 27.3 ml of oxalyl chloride. After stirring at room temperature for 4 hours and evaporation of the solvent under reduced pressure, [R]-(-)-2-(p-fluorophenyl)-3-methylbutyryl chloride was obtained as an oil, b.p. 100°/65 Pa; [α]D20 =-53.2° (c=1, chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05120759 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-780617868d24437b89f4ad6206afb1b4 |
| Source note | uspto-grants-1992_06 |