反应详情

A solution of 32.3 g (0.165 mol) of [R]-(-)-2-(p-fluorophenyl)-3-methylbutyric acid in 250 ml of abs. methylene chloride was treated with 27.3 ml of oxalyl chloride. After stirring at room temperature for 4 hours and evaporation of the solvent under reduced pressure, [R]-(-)-2-(p-fluorophenyl)-3-methylbutyryl chloride was obtained as an oil, b.p. 100°/65 Pa; [α]D20 =-53.2° (c=1, chloroform).

1. customevaporation of the solvent under reduced pressure