4-Methoxybenzaldehyde → HCID 14459961, compound

HRID 892821Notes

Reaction equation

HRID 892821 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][C:7]([CH2:8][CH:9]2[S:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH:18](=O)[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1>C(O)C.O>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19](/[CH:18]=[CH:2]/[C:1]([C:4]2[CH:17]=[CH:16][C:7]([CH2:8][CH:9]3[S:13][C:12](=[O:14])[NH:11][C:10]3=[O:15])=[CH:6][CH:5]=2)=[O:3])=[CH:20][CH:21]=1

Participants

5

Reactant 2

HCID 312444-MethoxybenzaldehydeHCID 14456701HCID 14456701, compound

Product 1

HCID 14459961HCID 14459961, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Hydrogen chloride was bubbled into an ice-cooled solution of 5-(4-acetylbenzyl)thiazolidine-2,4-dione (1.0 g, 4.0 mmol) and p-anisaldehyde (0.55 g, 4.0 mol) in ethanol (15 ml) for 1 hour. The solution was stirred overnight at room temperature, then diluted with water and the yellow precipitate of present title product collected and dried (1.37 g, 93%); m.p. 177°-180° C.

Workup

  1. customHydrogen chloride was bubbled into an ice-
  2. customthe yellow precipitate of present title product collected
  3. customdried (1.37 g, 93%)

Sources & evidence

ORD record
ord-6e74c1eb06a24abc91b50ffe6642d0a1
Source dataset
uspto-grants-1992_06
Patent number
US05120754

Reaction notes

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