反应详情

4-Phenoxyphenol (25.0 g, 134 mmol) is taken up in a mixture of pyridine (51 mL) and acetic anhydride (58 mL) and heated at reflux for 2 hours. The mixture is cooled and poured into 300 mL of water. The solution is made acidic with 2N hydrochloric acid and extracted three times with ether. The organic phase is washed with aqueous sodium bicarbonate solution, dried over magnesium sulfate and evaporated. Purification of the residue by silica-gel flash chromatography (4:1 hexane/ethyl acetate) gives 4-phenoxyphenyl acetate as a colorless solid.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. temperatureThe mixture is cooled
4. extractionextracted three times with ether
5. washThe organic phase is washed with aqueous sodium bicarbonate solution
6. dry with materialdried over magnesium sulfate
7. customevaporated
8. customPurification of the residue by silica-gel flash chromatography (4:1 hexane/ethyl acetate)