反应详情

2-Benzyloxy-5-phenoxybenzaldehyde (22.25 g, 73 mmol) is dissolved in methanol (200 mL) and treated with hydrogen peroxide (31% in water, 32.0 mL) and concentrated sulfuric acid (15.0 mL). The mixture is stirred overnight at room temperature and evaporated. The residue is dissolved in saturated aqueous sodium chloride solution and extracted with ether. The organic phase is dried over magnesium sulfate and evaporated. Purification of the residue by silica-gel flash chromatography gives 2-benzyloxy-5-phenoxyphenol as a colorless solid.

1. customevaporated
2. dissolutionThe residue is dissolved in saturated aqueous sodium chloride solution
3. extractionextracted with ether
4. dry with materialThe organic phase is dried over magnesium sulfate
5. customevaporated
6. customPurification of the residue by silica-gel flash chromatography