Potassium Carbonate → 118138-22-0

HRID 892859Notes

Reaction equation

HRID 892859 reaction equation
C([O:4][CH2:5][C@H:6]1[C@H:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]1([F:16])[F:15])(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[F:15][C:7]1([F:16])[C@@H:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C@@H:6]1[CH2:5][OH:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 12575330HCID 12575330, compound

Product 1

HCID 13201700118138-22-0Yield 96.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of trans-1-acetoxymethyl-2,2-difluoro-3-phenylcyclopropane (9.7 mmol, prepare according to Kobayashi et al. J. Org. Chem, 1982, 47, 3232) in methanol (50 mL) was added K2CO3 (1.34 g, 9.7 mmol) and the reaction was stirred for 20 mins. The solution was then decanted from the solids and concentrated. The residue was purified by column chromatography (silica gel, ether:hexanes, 35:65) to afford 1.72 g (96%) of trans-2,2-difluoro-1-hydroxymethyl-3-phenylcyclopropane.

Workup

  1. customThe solution was then decanted from the solids
  2. concentrationconcentrated
  3. customThe residue was purified by column chromatography (silica gel, ether:hexanes, 35:65)

Sources & evidence

ORD record
ord-79bd61191b0643438828d7cc95aea840
Source dataset
uspto-grants-1992_06
Patent number
US05120752

Reaction notes

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