反应详情

A solution of 3.0 g of oleyl chloride in 10 mg of methylene chloride was added portion-wise to a solution of 4.3 g of piperazine in 30 ml of methylene chloride with stirring under ice cooling. After stirring the mixture in situ for additional 2 hours, 10 ml of water was added to the reaction mixture to separate the organic layer. The organic layer was further washed with water and dried over anhydrous sodium sulfate, followed by removal of the solvent by evaporation. The residue obtained was purified by silica gel column chromatography to obtain 2.68 g of the objective compound (yield: 76%).

1. stirringAfter stirring the mixture in situ for additional 2 hours
2. customto separate the organic layer
3. washThe organic layer was further washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customfollowed by removal of the solvent by evaporation
6. customThe residue obtained
7. customwas purified by silica gel column chromatography