Water → HCID 19894514, compound

HRID 892923Notes

Reaction equation

HRID 892923 reaction equation
[C:1](=[O:13])([O:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)[O:2][CH:3](Cl)[CH2:4][CH3:5].[I-:14].[Na+].CCOCC.O>C(#N)C>[C:1](=[O:13])([O:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)[O:2][CH:3]([I:14])[CH2:4][CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 5238Sodium IodideHCID 19894509HCID 19894509, compound

Product 1

HCID 19894514HCID 19894514, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 3.11 g of 1-chloropropyl cyclopentyl carbonate and 6 g of sodium iodide in 40 ml of acetonitrile is stirred at 60° C. for 60 minutes and then concentrated under reduced pressure. The residue obtained is distributed with 100 ml of ether and 100 ml of water. The ether layer is separated, washed serially with 50 ml of 5% sodium thiosulfate and 100 ml of saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound as oily material.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue obtained
  3. customThe ether layer is separated
  4. washwashed serially with 50 ml of 5% sodium thiosulfate and 100 ml of saturated aqueous solution of sodium chloride
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-1599ee0ade924a4cbae678253a97788a
Source dataset
uspto-grants-1992_06
Patent number
US05120841

Reaction notes

Loading…