HCID 19748502, compound → 2-(1-AMINOETHYL)PHENOL HYDROCHLORIDE

HRID 892936Notes

Reaction equation

HRID 892936 reaction equation
[ClH:1].C([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17])C1C=CC=CC=1>[Pd].CO>[ClH:1].[OH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17]

Participants

4

Reactant 1

HCID 19748502HCID 19748502, compound

Product 1

HCID 197485242-(1-AMINOETHYL)PHENOL HYDROCHLORIDEYield 102.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture obtained by adding 2.64 g of (+)-1-(2-benzyloxyphenyl)ethylamine hydrochloride prepared in Referential Example (3-1) and 0.26 g of 5% Pd-C to 40 ml of methanol was subjected to hydrogenation at room temperature and normal pressure, whereby 256 ml of hydrogen was absorbed. After filtering off the catalyst, the filtrate was concentrated under reduced pressure to give 1.78 g of (+)-1-(2-hydroxyphenyl)ethylamine hydrochloride.

Workup

  1. customA mixture obtained
  2. customwas subjected to hydrogenation at room temperature
  3. customnormal pressure, whereby 256 ml of hydrogen was absorbed
  4. filtrationAfter filtering off the catalyst
  5. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4b107e0caab545a3820dcee34921607a
Source dataset
uspto-grants-1992_06
Patent number
US05120853

Reaction notes

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