Hydrochloric Acid → 2-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride

HRID 892938Notes

Reaction equation

C([NH:3][C:4]([CH3:21])([CH:18]([CH3:20])[CH3:19])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6])=O.[ClH:22]>CO.O>[ClH:22].[NH2:3][C:4]([CH3:21])([CH:18]([CH3:19])[CH3:20])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6]

Participants

Conditions

Temperature: 80 °C

Procedure

A suspension of 2-formamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide (99.4 g, 0.318 mols) in 500 mL of methanol, 500 mL of water, and 500 mL of aqueous HCl 10% is heated at 80° C. until all the solid has dissolved (one hour). The reaction mixture is concentrated to 1/3 of the volume and the resulting precipitate is filtered off. After drying the title product is obtained as a white solid, having mp 161°-165° C.

Workup

dissolutionhas dissolved (one hour)
concentrationThe reaction mixture is concentrated to 1/3 of the volume
filtrationthe resulting precipitate is filtered off
dry with materialAfter drying the title product
customis obtained as a white solid

Sources & evidence

ORD record: ord-ff06927b85af4de6b4343295b65cd81c
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05120854

Reaction notes

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