HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 32507-69-0
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(4-Hydroxyphenyl)imidazolidine-2,4-dione | HCID 94233 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Catalyst | Sodium Dithionite | HCID 24489 | — |
| Solvent | Water | HCID 962 | — |
| Product | 32507-69-0 | HCID 578941 | 95% |
Reaction Steps
Crude 5-(p-hydroxyphenyl)hydantoin (85.6 g) is placed in a 1-liter round bottom flask with 41 g hydroxylamine sulfate, 1 g Na2S2O4, 60 g NaOH, and 300 ml H2O. The contents are refluxed for 1 hour and then cooled in an ice bath. Then 125 ml cold concentrated HCl are added. The solids are filtered and washed with 200 ml H2O. The solids are dried in a vacuum oven at 60° C. over the weekend yielding 58.8 g of ca. 95% pure p-hydroxyphenylhydantoic acid (by HPLC analysis).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05120855 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-41145e644ce04a3eb55d45e91bf58337 |
| Source note | uspto-grants-1992_06 |