反应详情

Crude 5-(p-hydroxyphenyl)hydantoin (85.6 g) is placed in a 1-liter round bottom flask with 41 g hydroxylamine sulfate, 1 g Na2S2O4, 60 g NaOH, and 300 ml H2O. The contents are refluxed for 1 hour and then cooled in an ice bath. Then 125 ml cold concentrated HCl are added. The solids are filtered and washed with 200 ml H2O. The solids are dried in a vacuum oven at 60° C. over the weekend yielding 58.8 g of ca. 95% pure p-hydroxyphenylhydantoic acid (by HPLC analysis).

1. temperatureThe contents are refluxed for 1 hour
2. temperaturecooled in an ice bath
3. filtrationThe solids are filtered
4. washwashed with 200 ml H2O
5. customThe solids are dried in a vacuum oven at 60° C. over the weekend