Hydrochloric Acid → HCID 23174739, compound

HRID 892949Notes

Reaction equation

[OH:1][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[ClH:13]>>[OH:1][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[ClH:13]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 20468917HCID 20468917, compound

Product 1

HCID 23174739HCID 23174739, compound

Procedure

The method of claim 41, wherein the optical resolution is conducted by reacting DL-hydroxyphenylglycine with HCl to form DL-hydroxyphenylglycine·HCl, reacting DL-hydroxyphenylglycine·HCl with a (+)-phenylethanesulfate to form DL-hydroxyphenylglycine (+)-phenylethanesulfate, then heating and crystallizing to produce D-hydroxyphenylglycine (+)-phenylethanesulfate and reacting with methanol and an aqueous sodium hydroxide solution to give D-hydroxyphenylglycine.

Sources & evidence

ORD record: ord-a7f102960bc34e9db9eb2329ee688c10
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05120855

Reaction notes

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