Glycine → HCID 131717430, compound

HRID 893048Notes

Reaction equation

HRID 893048 reaction equation
Cl.N1C=C[CH:5]=[CH:4][C:3]=1[NH:8][CH2:9][C:10]([OH:12])=O.[NH2:13][CH2:14][C:15]([OH:17])=O.N1C=CC=CC=1NCC(O)=[O:27].C1(N=C=NC2CCCCC2)CCCCC1.[CH2:44]([O:46][C:47](=[O:50])[CH2:48][NH2:49])[CH3:45]>ClCCl>[NH:8]1[C:3](=[O:27])[CH2:4][CH2:5][C@H:9]1[C:10]([NH:13][CH2:14][C:15]([NH:49][CH2:48][C:47]([O:46][CH2:44][CH3:45])=[O:50])=[O:17])=[O:12]

Participants

7

Reactant 5

HCID 750GlycineHCID 10868DicyclohexylcarbodiimideHCID 12176Glycine ethyl esterHCID 193885N-(2-Pyridyl)glycineHCID 14238451N-Pyridin-2-ylglycine--hydrogen chloride (1/1)

Product 1

HCID 131717430HCID 131717430, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The synthesis of peptide bond reaction from the 2-pyridylglycine.hydrochloride and glycine can be carried out, for example, as follows: To N-2-pyridylglycine, are added dichloromethane, N,N'-dicyclohexylcarbodiimide and glycine ethyl ester. After stirring at room temperature for several hours, the reaction solution is filtered. The filtrate is purified by using, for example, high performance liquid chromatography to give Pyr-Gly-Gly-OEt.

Workup

  1. filtrationthe reaction solution is filtered
  2. customThe filtrate is purified

Sources & evidence

ORD record
ord-d83689969c604495b735948d06870adc
Source dataset
uspto-grants-1992_06
Patent number
US05120644

Reaction notes

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