Diethyl (ethoxymethylene)malonate → HCID 15045621, compound

HRID 893067Notes

Reaction equation

HRID 893067 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O[CH:18]=[C:19]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:20]([O:22][CH2:23][CH3:24])=[O:21])C>C(O)C>[CH2:28]([O:27][C:25]([C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:18][NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)=[O:26])[CH3:29]

Participants

4

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 15045621HCID 15045621, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution containing 0.38 g of 6-(4-aminophenyl)-4,5-dihydropyridazin-3(2H)one and 0.45 g of diethyl ethoxymethylenemalonate in 5 ml of dry ethanol was refluxed for 1.5 h. After cooling the product was filtered and washed with ethanol. Yield 0.3 g, mp 164° C.

Workup

  1. temperaturewas refluxed for 1.5 h
  2. temperatureAfter cooling the product
  3. filtrationwas filtered
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-639b1fcef63848838ec51623dad39914
Source dataset
uspto-grants-1992_06
Patent number
US05122524

Reaction notes

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