L-Hydroxyproline → HCID 15671477, compound

HRID 893172Notes

Reaction equation

HRID 893172 reaction equation
[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:7]([OH:9])=[O:8])[CH2:3]1.[CH3:10][O:11][C:12]1[CH:30]=[CH:29][C:15]([CH2:16][O:17][C:18](SC2N=C(C)C=C(C)N=2)=[O:19])=[CH:14][CH:13]=1>>[CH3:10][O:11][C:12]1[CH:30]=[CH:29][C:15]([CH2:16][O:17][C:18]([N:5]2[CH2:6][C@H:2]([OH:1])[CH2:3][C@H:4]2[C:7]([OH:9])=[O:8])=[O:19])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5810L-HydroxyprolineHCID 100623S-(4,6-Dimethylpyrimidin-2-yl) O-(p-methoxybenzyl) thiocarbonate

Product 1

HCID 15671477HCID 15671477, compound

Procedure

In the same manner as described in Reference Example 1--1 but using 10 g of trans-4-hydroxy-L-proline and 23.2 g of S-p-methoxybenzyloxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine, trans-1-(p-methoxybenzyloxycarbonyl)-4-hydroxy-L-proline was obtained.

Sources & evidence

ORD record
ord-cfafde89c3ef481e94ca7bb6888ff85f
Source dataset
uspto-grants-1992_06
Patent number
US05122604

Reaction notes

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