Hydrochloric Acid → HCID 19096853, compound

Participants

Reaction Steps

A 2.0 gram (0.006 mole) portion of ethyl 1-(3,5-dichlorophenylaminocarbonyl)cyclobutanecarboxylate prepared in Example X (Compound 130) was hydrolyzed in the presence of water (0.114 gram, 0.006 mole) and ethanolic potassium hydroxide (0.355 gram, 0.006 mole). The potassium salt of the acid was then acidified with 25% HCl solution and worked up in a manner similar to that described in Example VII to give 0.92 gram (0.003 mole) of 1-(3,5-dichlorophenylaminocarbonyl)cyclobutanecarboxylic acid as a beige-colored solid having a melting point of 159° C.-160° C.

Provenance & Evidence