Hydrochloric Acid → HCID 19096853, compound

HRID 893195Notes

Reaction equation

HRID 893195 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2([C:16]([O:18]CC)=[O:17])[CH2:15][CH2:14][CH2:13]2)=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.O.[OH-].[K+].[K].Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][CH2:13]2)=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 19096840HCID 19096840, compound2×

Product 1

HCID 19096853HCID 19096853, compound

Procedure

A 2.0 gram (0.006 mole) portion of ethyl 1-(3,5-dichlorophenylaminocarbonyl)cyclobutanecarboxylate prepared in Example X (Compound 130) was hydrolyzed in the presence of water (0.114 gram, 0.006 mole) and ethanolic potassium hydroxide (0.355 gram, 0.006 mole). The potassium salt of the acid was then acidified with 25% HCl solution and worked up in a manner similar to that described in Example VII to give 0.92 gram (0.003 mole) of 1-(3,5-dichlorophenylaminocarbonyl)cyclobutanecarboxylic acid as a beige-colored solid having a melting point of 159° C.-160° C.

Sources & evidence

ORD record
ord-3195f73dd2914fb5ae5d3f5a112d699f
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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