HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 13551145, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | 2-Ethylpropanedioyl dichloride | HCID 10920924 | — |
| Product | HCID 13551145 | HCID 13551145 | — |
Reaction Steps
In a manner similar to the procedure described in Example I, 2-amino-4-methylthiazole was reacted with ethyl malonyl chloride employing triethylamine as the acid acceptor in tetrahydrofuran solution. The ethyl 3-[(4-methylthiazol-2-yl)amino]-3-oxopropanoate product (7.5 grams, 0.03 mole) was obtained as an off-white solid having a melting point of 138° C.-141° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05123951 |
| Source dataset | uspto-grants-1992_06 |
| ORD ID | ord-33bf63d2483d4f949987b7924963db6a |
| Source note | uspto-grants-1992_06 |