Tetrahydrofuran → HCID 13551145, compound

HRID 893200Notes

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:7])[N:6]=1.C([CH:10]([C:14](Cl)=[O:15])[C:11](Cl)=[O:12])C.C(N([CH2:22][CH3:23])CC)C.[O:24]1CCCC1>>[CH3:7][C:5]1[N:6]=[C:2]([NH:1][C:14](=[O:15])[CH2:10][C:11]([O:12][CH2:22][CH3:23])=[O:24])[S:3][CH:4]=1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 741432-Amino-4-methylthiazole

HCID 109209242-Ethylpropanedioyl dichloride

Product 1

HCID 13551145HCID 13551145, compound

Procedure

In a manner similar to the procedure described in Example I, 2-amino-4-methylthiazole was reacted with ethyl malonyl chloride employing triethylamine as the acid acceptor in tetrahydrofuran solution. The ethyl 3-[(4-methylthiazol-2-yl)amino]-3-oxopropanoate product (7.5 grams, 0.03 mole) was obtained as an off-white solid having a melting point of 138° C.-141° C.

Sources & evidence

ORD record: ord-33bf63d2483d4f949987b7924963db6a
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05123951

Reaction notes

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