Triethylamine → HCID 19096846, compound

HRID 893221Notes

Reaction equation

HRID 893221 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.Cl[C:11]([C:13]([O:20][CH3:21])([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:12].C(N(CC)CC)C>C(Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11](=[O:12])[C:13]([O:20][CH3:21])([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH3:9])[CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 114234-Bromo-2-methylanilineHCID 19096847Ethyl 2-(chlorocarbonyl)-2-methoxypropionate

Product 1

HCID 19096846HCID 19096846, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Bromo-2-methylaniline (2.83 grams, 0.02 mole) and ethyl 2-(chlorocarbonyl)-2-methoxypropionate (4.12 grams, 0.02 mole), prepared in Part C, were reacted in the presence of triethylamine (1.54 grams, (0.02 mole) in 200 milliliters of methylene chloride in a manner similar to that described in Example I to give 1.73 grams (0.005 mole) of ethyl 3-[(4-bromo-2-methyl-phenyl)amino]-2-methoxy-2-methyl-3-oxopropanoate having a melting point of 99° C.-103° C.

Sources & evidence

ORD record
ord-f0c47b1bcbfb42d7a2a44f832d81327c
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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