Dicyclohexylcarbodiimide → HCID 19096860, compound

HRID 893231Notes

Reaction equation

HRID 893231 reaction equation
[CH3:1][O:2][CH:3]([C:11]([O-:13])=O)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[Cl:14][C:15]1[CH:16]=[C:17]([CH:19]=[C:20]([Cl:22])[CH:21]=1)[NH2:18].C1(N=C=NC2CCCCC2)CCCCC1>>[Cl:14][C:15]1[CH:16]=[C:17]([NH:18][C:11](=[O:13])[CH:3]([O:2][CH3:1])[C:4]([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])=[O:5])[CH:19]=[C:20]([Cl:22])[CH:21]=1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 122813,5-DichloroanilineHCID 86094033HCID 86094033, compound

Product 1

HCID 19096860HCID 19096860, compoundYield 30%

Procedure

Mono-t-butyl methoxymalonate (5.42 grams, 0.03 mole), prepared in Part B, 3,5-dichloroaniline (4.62 grams, 0.03 mole) and 1,3-dicyclohexylcarbodiimide (5.88 grams, 0.03 mole) were reacted in a manner similar to that described in Example LVII to give 2.92 grams (0.009 mole) of t-butyl 3-[(3,5-dichlorophenyl)amino]-2-methoxy-3-oxopropanoate having a melting point of 129.5° C.-131.5° C.

Workup

  1. customwere reacted in a manner similar to

Sources & evidence

ORD record
ord-9639866325274912958d9249382d6366
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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