Dicyclohexylcarbodiimide → HCID 19096831, compound

HRID 893235Notes

Reaction equation

HRID 893235 reaction equation
[CH2:1]([CH:3]([C:9]([O-:11])=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[Cl:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([Cl:20])[CH:19]=1)[NH2:16].C1(N=C=NC2CCCCC2)CCCCC1>>[Cl:12][C:13]1[CH:14]=[C:15]([NH:16][C:9]([CH:3]([CH2:1][CH3:2])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[O:11])[CH:17]=[C:18]([Cl:20])[CH:19]=1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 122813,5-DichloroanilineHCID 189590342-(Ethoxycarbonyl)butanoate

Product 1

HCID 19096831HCID 19096831, compoundYield 10%

Procedure

Mono-ethyl ethylmalonate (5.0 grams, 0.03 mole), 3,5-dichloroaniline (5.06 grams, 0.03 mole) and 1,3-dicyclohexylcarbodiimide (6.44 grams, 0.03 mole) were reacted in a manner similar to that described in Example LVII to give 0.87 gram (0.003 mole) of ethyl 2-(3,5-dichlorophenylaminocarbonyl)butanoate having a melting point of 96.5° C.-98° C.

Sources & evidence

ORD record
ord-2b1131c7c0864c868e183e5d9f607bf3
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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