Methyl iodide → HCID 19891954, compound

HRID 893277Notes

Reaction equation

HRID 893277 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][N:15]2[CH3:20])=[O:11])=[CH:2]1.[CH3:21][I:22]>C1C=CC=CC=1>[I-:22].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][N+:15]2([CH3:21])[CH3:20])=[O:11])=[CH:2]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19891949(1-Methyl-2-piperidinyl)methyl 1H-indole-3-carboxylate

Product 1

HCID 19891954HCID 19891954, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

In benzene (10 ml) was dissolved by heating (1-methyl-2-piperidyl)methyl 1H-indole-3-carboxylate (0.10 g, 0.37 mmol) followed by addition of a benzene (5 ml) solution of methyl iodide (0.14 g, 0.99 mmol). The mixture was allowed to react in a stainless steel sealed tube at 100° C. for 2 hours. The reaction tube was cooled, and a reaction product was scraped out by a spatula, washed with IPE and dried (70° C.) under reduced pressure to give 0.11 g of the title compound as a yellow foamy solid. m.p. 95°-97° C.;

Workup

  1. customto react in a stainless steel sealed tube at 100° C. for 2 hours
  2. temperatureThe reaction tube was cooled
  3. washwashed with IPE
  4. customdried (70° C.) under reduced pressure

Sources & evidence

ORD record
ord-e1e0ac91c34b4dcd9649ec5d5ec95e12
Source dataset
uspto-grants-1992_06
Patent number
US05124324

Reaction notes

Loading…