反应详情

To a DMF (3 ml) solution of 2-piperidinemethanol (1.00 g, 8.7 mmol) and imidazole (1.48 g, 21.7 mmol) was added tert-butyldimethylchlorosilane (1.57 g, 10.4 mmol) at room temperature. After stirring for 30 min., a reaction solution was poured onto water followed by extraction with diethyl ether (about 30 ml). The extract was washed successively with water and saturated aqueous sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to afford 1.61 g of the title compound.

1. additiona reaction solution was poured onto water
2. extractionfollowed by extraction with diethyl ether (about 30 ml)
3. washThe extract was washed successively with water and saturated aqueous sodium chloride
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was removed under reduced pressure