Azane;hydrate → HCID 14653250, compound

HRID 893305Notes

Reaction equation

HRID 893305 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[C:16]([S:18](Cl)(=[O:20])=[O:19])[S:17][C:11]=2[N:10]=[C:9]1[CH3:22].O.[NH3:24]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[C:16]([S:18](=[O:20])(=[O:19])[NH2:24])[S:17][C:11]=2[N:10]=[C:9]1[CH3:22]

Participants

4

Reactant 2

HCID 12896473Azane;hydrateHCID 14653249HCID 14653249, compound

Product 1

HCID 14653250HCID 14653250, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In 200 ml of tetrahydrofuran was suspended 23 g of 3,4-dihydro-3-(2-chlorophenyl)-6-chlorosulfonyl-2-methyl-4-oxothieno[2,3-d]pyrimidine, and this suspension was poured onto 200 ml of ammonia water at one time. The mixture was stirred at room temperature for 40 minutes. The reaction mixture was concentrated, and water was added to the residue. The crystals were collected by suction-filtration to afford 15.8 g of the title compound, m.p. 251° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added to the residue
  3. filtrationThe crystals were collected by suction-filtration

Sources & evidence

ORD record
ord-04361305d37c46f8bd57daf3a944b26f
Source dataset
uspto-grants-1992_06
Patent number
US05124331

Reaction notes

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