Hydrochloric Acid → HCID 14653256, compound

HRID 893309Notes

Reaction equation

HRID 893309 reaction equation
C([O:4][CH2:5][C:6]1[N:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[C:8](=[O:19])[C:9]2[CH:14]=[C:13]([S:15](=[O:18])(=[O:17])[NH2:16])[S:12][C:10]=2[N:11]=1)(=O)C.CO.Cl>O>[Cl:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[N:7]1[C:8](=[O:19])[C:9]2[CH:14]=[C:13]([S:15](=[O:17])(=[O:18])[NH2:16])[S:12][C:10]=2[N:11]=[C:6]1[CH2:5][OH:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14653255HCID 14653255, compound

Product 1

HCID 14653256HCID 14653256, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 9.3 g of 3,4-dihydro-2-acetoxymethyl-3-(2-chlorophenyl)-4-oxo-6-sulfamoylthieno[2,3-d]pyrimidine were added 200 ml of methanol, 30 ml of water and 14.3 ml of conc. hydrochloric acid, and the mixture was stirred under reflux for 2 hours. The reaction mixture was concentrated, and the residue was crystallized from methanol to give 6.2 g of pale yellow crystals, which was recrystallized from methanol to afford 2.6 g of the title compound, m.p. 259° C. (decomposition).

Workup

  1. temperatureunder reflux for 2 hours
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was crystallized from methanol

Sources & evidence

ORD record
ord-8b61d2f1e1064365a819cef485183d50
Source dataset
uspto-grants-1992_06
Patent number
US05124331

Reaction notes

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