Lithium Hydroxide → HCID 15341821, compound

HRID 893464Notes

Reaction equation

HRID 893464 reaction equation
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH2:32][CH3:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH2:32][CH3:33])[C:5]=1[O:34][CH3:35])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341820HCID 15341820, compound

Product 1

HCID 15341821HCID 15341821, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 42 (90 mg, 0.1845 mmol) and 369 μl of 1 M lithium hydroxide were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum, 10 ml of water was added, and the solution was acidified with dilute hydrochloric acid then stirred for 1 hour. The white precipitate that formed was removed by filtration and dried at 40° C. in a vacuum oven to give the product.

Workup

  1. customThe solvent was removed under vacuum, 10 ml of water
  2. additionwas added
  3. stirringthen stirred for 1 hour
  4. customThe white precipitate that formed
  5. customwas removed by filtration
  6. customdried at 40° C. in a vacuum oven
  7. customto give the product

Sources & evidence

ORD record
ord-96dbbaa6da124dafbc382d0a477e1683
Source dataset
uspto-grants-1992_06
Patent number
US05124350

Reaction notes

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