Phosphorus oxychloride → Phosphorodichloridic acid-3-bromo-2,2 dimethylpropyl ester

HRID 893583Notes

Reaction equation

HRID 893583 reaction equation
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Br:6][CH2:7][C:8]([CH3:12])([CH3:11])[CH2:9][OH:10]>C(Cl)(Cl)(Cl)Cl>[Br:6][CH2:7][C:8]([CH3:12])([CH3:11])[CH2:9][O:10][P:1]([Cl:5])([Cl:3])=[O:2]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1425013-Bromo-2,2-dimethyl-1-propanol

Product 1

HCID 14256203Phosphorodichloridic acid-3-bromo-2,2 dimethylpropyl ester

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

To a solution of 18.35 g of phosphorous oxychloride in 55 ml of carbon tetrachloride was added dropwise a solution of 3-bromo-2,2-dimethyl-1-propanol in 20 ml of carbon tetrachloride. This mixture was stirred overnight, evaporated in vacuo, then evaporated twice from toluene at 35° C. and dried. The residue was distilled on Kugelrohr 100° C., 0.3 mm giving the desired compound as a colorless oil.

Workup

  1. customevaporated in vacuo
  2. customevaporated twice from toluene at 35° C.
  3. customdried
  4. distillationThe residue was distilled on Kugelrohr 100° C., 0.3 mm

Sources & evidence

ORD record
ord-d003280b775e44df9fe8567172fffc59
Source dataset
uspto-grants-1992_06
Patent number
US05126291

Reaction notes

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