Sodium Hydroxide → HCID 19890936, compound

HRID 893634Notes

Reaction equation

HRID 893634 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][Se:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[O:14].[OH-].[Na+]>O>[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][Se:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[C:13]([NH:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)=[O:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19890935HCID 19890935, compound

Product 1

HCID 19890936HCID 19890936, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.5 g (0.00113 mol) 2-(2-picolylseleno)-N-(4-pyridyl)benzamide dihydrochloride from Example 5 in 2 ml H2O is made alkaline with 10 N NaOH and extracted twice with 5 ml portions of dichloromethane. The organic phase is dried over magnesium sulfate, the solvent removed and the crude product recrystallized from 15 ml 2-propanol.

Workup

  1. extractionextracted twice with 5 ml portions of dichloromethane
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. customthe solvent removed
  4. customthe crude product recrystallized from 15 ml 2-propanol

Sources & evidence

ORD record
ord-ac47ec2cefd94c52bec09dd3c1b2d0b8
Source dataset
uspto-grants-1992_06
Patent number
US05126357

Reaction notes

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