Thionyl Chloride → 1-Cyclobutyl-3-methyl-1H-pyrazole-5-carbonyl chloride

HRID 893642Notes

Reaction equation

HRID 893642 reaction equation
[CH:1]1([N:5]2[C:9]([C:10](O)=[O:11])=[CH:8][C:7]([CH3:13])=[N:6]2)[CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:16])=O>C1C=CC=CC=1>[CH:1]1([N:5]2[C:9]([C:10]([Cl:16])=[O:11])=[CH:8][C:7]([CH3:13])=[N:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15136779129506-38-3

Product 1

HCID 151367811-Cyclobutyl-3-methyl-1H-pyrazole-5-carbonyl chlorideYield 96.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 3.02 g of 1-cyclobutyl-3-methyl-1H-pyrazole-5-carboxylic acid were added 60 ml of benzene and 10 ml of thionyl chloride. The mixture was refluxed for two hours. Then the solvent was distilled off under reduced pressure and thus 3.2 g of 1-cyclobutyl-3-methyl-1H-pyrazole-5-carboxylic acid chloride was obtained (yield: 96.1%).

Workup

  1. temperatureThe mixture was refluxed for two hours
  2. distillationThen the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-ffadd85cf4ba485aa0e18c812058bc48
Source dataset
uspto-grants-1992_06
Patent number
US05126362

Reaction notes

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