Sodium cyanoborohydride → 3-Chloro-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

HRID 893647Notes

Reaction equation

HRID 893647 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH:8]=[N:7][C:6]=12.C([BH3-])#N.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=3)=[CH:9][CH2:8][NH:7][C:6]=12

Participants

4

Reactant 2

HCID 5003444Sodium cyanoborohydrideHCID 197562203-Chloro-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

Product 1

HCID 1361838583-Chloro-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 13.3 g portion of 3-chloro-7-[3-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine and 7 g of sodium cyanoborohydride in 50 ml of acetic acid, were reacted as described in Example 1, giving 6.7 g of 3-chloro-4,5-dihydro-7-[3-(trifluoromethyl) phenyl]pyrazolo[1,5-a]pyrimidine.

Sources & evidence

ORD record
ord-43b683ca571444078e6f050042f8cad3
Source dataset
uspto-grants-1992_06
Patent number
US05126340

Reaction notes

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