Hydrochloric Acid → HCID 131716676, compound

Participants

Reaction Steps

A 6.6 g portion of 4-[[4-(4-fluorophenyl)-1-piperazinyl]acetyl]-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile was heated to solution in 100 ml of ethyl acetate, then cooled and acidified with 25 ml of 2.44 N ethanolic hydrochloric acid. Ether was added, the solid collected, heated to boiling in 500 ml of ethanol, then cooled and the crystalline salt collected, giving 5.7 g of the desired product, mp 242°-244° C.

Provenance & Evidence