Hydrochloric Acid → HCID 131716676, compound

HRID 893654Notes

Reaction equation

HRID 893654 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]3[CH2:22][CH:21]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=4)[N:19]4[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:18]34)=[O:16])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[ClH:38].CCOCC>C(OCC)(=O)C>[ClH:38].[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]3[CH2:22][CH:21]=[C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:31])([F:30])[F:32])[CH:24]=4)[N:19]4[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:18]34)=[O:16])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15100986HCID 15100986, compound

Product 1

HCID 131716676HCID 131716676, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 6.6 g portion of 4-[[4-(4-fluorophenyl)-1-piperazinyl]acetyl]-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile was heated to solution in 100 ml of ethyl acetate, then cooled and acidified with 25 ml of 2.44 N ethanolic hydrochloric acid. Ether was added, the solid collected, heated to boiling in 500 ml of ethanol, then cooled and the crystalline salt collected, giving 5.7 g of the desired product, mp 242°-244° C.

Workup

  1. temperaturecooled
  2. customthe solid collected
  3. temperatureheated
  4. temperaturecooled
  5. customthe crystalline salt collected

Sources & evidence

ORD record
ord-ee9ba1a4a89940bd95a4041b64220988
Source dataset
uspto-grants-1992_06
Patent number
US05126340

Reaction notes

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