Phthaloyl chloride → HCID 54228578, compound

HRID 893818Notes

Reaction equation

[F:1][C@@:2]([C:10]([F:13])([F:12])[F:11])([CH2:6][CH2:7][CH2:8][CH3:9])[C:3](O)=[O:4].C1C=C(C([Cl:22])=O)C(C(Cl)=O)=CC=1>>[F:1][C@@:2]([C:10]([F:13])([F:12])[F:11])([CH2:6][CH2:7][CH2:8][CH3:9])[C:3]([Cl:22])=[O:4]

Participants

Reactant 2

HCID 6955Phthaloyl chloride

HCID 54037617HCID 54037617, compound

Product 1

HCID 54228578HCID 54228578, compoundYield 93.9%

Conditions

Temperature: 80 °C

Procedure

A mixture of 8.0 g of (S)-(-)-2-fluoro-2-(trifluoromethyl)hexanoic acid and 24.0 g of phthalyl chloride was stirred at 80° C. for 24 hours. Subsequently, the reaction mixture was distilled under reduced pressure, thereby obtaining 8.2 g of (R)-(-)-2-fluoro-2-(trifluoromethyl)hexanoyl chloride having the physical properties as mentioned hereinbefore.

Workup

distillationSubsequently, the reaction mixture was distilled under reduced pressure

Sources & evidence

ORD record: ord-117003a06c604e1498e58cf6a569cee7
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05126482

Reaction notes

Loading…