Methanol → HCID 53843919, compound

HRID 893819Notes

Reaction equation

HRID 893819 reaction equation
[F:1][C@@:2]([C:10]([F:13])([F:12])[F:11])([CH2:6][CH2:7][CH2:8][CH3:9])[C:3](Cl)=[O:4].[CH3:14][OH:15]>>[F:1][C@@:2]([C:10]([F:13])([F:12])[F:11])([CH2:6][CH2:7][CH2:8][CH3:9])[C:3]([O:15][CH3:14])=[O:4]

Participants

3

Reactant 2

HCID 887MethanolHCID 54228578HCID 54228578, compound

Product 1

HCID 53843919HCID 53843919, compound

Procedure

To 0.5 ml of methanol was added 0.17 g of (R)-(-)-2-fluoro-2-(trifluoromethyl)hexanoyl chloride, and this mixture was stirred at room temperature for 30 minutes. The resulting reaction mixture was distilled with Kugelrohr under atomspheric pressure, thereby obtaining 0.15 g of methyl (S)-(-)-2-fluoro-2-(trifluoromethyl)hexanoate having the physical properties as mentioned hereinbefore.

Workup

  1. customThe resulting reaction mixture
  2. distillationwas distilled with Kugelrohr under atomspheric pressure

Sources & evidence

ORD record
ord-720bb374e91a494a83f14fdfce0f199f
Source dataset
uspto-grants-1992_06
Patent number
US05126482

Reaction notes

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