Hydrochloric Acid → HCID 53700447, compound

In 80 ml of anhydrous ether was dissolved 7.30 g of (R)-(-)-2-fluoro-2-(trifluoromethyl)hexanoylchloride, and then 0.83 g of lithium aluminum hydride was portionwise added to the above-obtained solution while the solution was being cooled with ice. The resulting mixture was stirred for 30 minutes. Thereafter, 1N hydrochloric acid was portionwise added to the resulting reaction mixture while the mixture was being cooled with ice, and then a reaction product was extracted with ether. The resulting organic layer was dried with magnesium sulfate, the solvent was removed under reduced pressure, and then the residual product was distilled. Thus, 4.6 g of (S)-(+)-2-fluoro-2-(trifluoromethyl)-1-hexanol was obtained which had the physical properties as mentioned hereinbefore.

1. temperaturewas being cooled with ice
2. temperaturewas being cooled with ice
3. extractiona reaction product was extracted with ether
4. dry with materialThe resulting organic layer was dried with magnesium sulfate
5. customthe solvent was removed under reduced pressure
6. distillationthe residual product was distilled

ORD record

ord-5b89db08b72d4965ad879adb78ee18f3

Source dataset

uspto-grants-1992_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05126482