Triethylamine → HCID 19891203, compound

HRID 893865Notes

Reaction equation

HRID 893865 reaction equation
C([O:3][C:4]([C:6]1[CH2:7][S:8][C:9]23[CH:18]=[CH:17][CH:16]=[CH:15][C:10]2=[N:11][CH:12]=[CH:13][C:14]=13)=O)C.[NH2:19][NH2:20].C(N(CC)CC)C>CO>[S:8]1[C:9]23[CH:18]=[CH:17][CH:16]=[CH:15][C:10]2=[N:11][CH:12]=[CH:13][C:14]3=[C:6]([C:4]([NH:19][NH2:20])=[O:3])[CH2:7]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9321HydrazineHCID 69959905HCID 69959905, compound

Product 1

HCID 19891203HCID 19891203, compoundYield 34.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of desiccated methanol was dissolved 515 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and after adding thereto 252 mg of hydrazine.di-chloride and 700 μl of triethylamine, the mixture was stirred for 2 days. Then, after refluxing the mixture for 2 hours, the temperature was allowed to lower to room temperature and crystals thus deposited were collected by filtration to provide 169 mg (yield of 0%) of benzo[b]thieno[2,3-c]pyridine-3-carbohydrazide.

Workup

  1. additionafter adding
  2. temperatureThen, after refluxing the mixture for 2 hours
  3. customto lower to room temperature
  4. filtrationcrystals thus deposited were collected by filtration

Sources & evidence

ORD record
ord-84d209bf69dd482eb102c8edf841947d
Source dataset
uspto-grants-1992_06
Patent number
US05126448

Reaction notes

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