反应详情

N-Ethylaniline (48.4 g 0.4 m), triethylamine (40.4 g 0.4 m) and benzene (100 ml) are stirred together at room temperature and 2-chloroethanesulfonyl fluoride (58.6 g, 0.4 m) is added dropwise. The reaction mixture is heated at reflux for 1.5 hr. after the addition is completed. The reaction mixture is cooled and filtered to remove any insoluble salts, and the benzene is removed by distillation. The crude product is drowned into hexane (150 ml) and purified by filtration and washing with hexane. The product melts at 48°-50° C.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 1.5 hr
3. additionafter the addition
4. temperatureThe reaction mixture is cooled
5. filtrationfiltered
6. customto remove any insoluble salts
7. customthe benzene is removed by distillation
8. filtrationpurified by filtration
9. washwashing with hexane