Aspirin → Calcium aspirin

HRID 893927Notes

Reaction equation

HRID 893927 reaction equation
[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].C(=O)([O-])[O-].[Ca+2:18]>O>[CH3:1][C:2]([O:4][C:5]1[C:10]([C:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[CH3:1][C:2]([O:4][C:5]1[C:10]([C:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[Ca+2:18]

Participants

4

Reactant 2

HCID 2244Aspirin2×HCID 10112Calcium Carbonate

Product 1

HCID 6247Calcium aspirin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A stock solution of calcium aspirin is prepared by mixing 4.032 gm of aspirin and 1.120 gm of precipitated calcium carbonate with 50 ml of distilled water at 40°-50° C. until the solids are completely dissolved, then diluting to 60 ml with distilled water at ambient temperature to obtain a solution containing 67.2 mg/ml of aspirin equivalent. All dosing solutions are prepared by dilution of the stock solution with distilled water; the vehicle control is distilled water. All solutions are used within two hours of preparation, then discarded.

Workup

  1. dissolutionare completely dissolved
  2. customto obtain a solution
  3. distillationthe vehicle control is distilled water
  4. customAll solutions are used within two hours of preparation

Sources & evidence

ORD record
ord-f8cc4bafeeba471fbc0f1cc5db883aab
Source dataset
uspto-grants-1981_08
Patent number
US04282215

Reaction notes

Loading…