Aspirin → Calcium aspirin

Participants

Reaction Steps

A stock solution of calcium aspirin is prepared by mixing 4.032 gm of aspirin and 1.120 gm of precipitated calcium carbonate with 50 ml of distilled water at 40°-50° C. until the solids are completely dissolved, then diluting to 60 ml with distilled water at ambient temperature to obtain a solution containing 67.2 mg/ml of aspirin equivalent. All dosing solutions are prepared by dilution of the stock solution with distilled water; the vehicle control is distilled water. All solutions are used within two hours of preparation, then discarded.

Provenance & Evidence