Water → HCID 18793861, compound

HRID 893937Notes

Reaction equation

HRID 893937 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6]1[N:7]=[CH:8][S:9][CH:10]=1)[CH3:2].[OH2:12]>ClCCCl>[CH2:1]([O:3][C:4](=[O:11])[C:5]([C:6]1[N:7]=[CH:8][S:9][CH:10]=1)=[O:12])[CH3:2]

Participants

4

Reactant 2

HCID 962WaterHCID 4737345Ethyl 2-(1,3-thiazol-4-yl)acetate

Product 1

HCID 18793861HCID 18793861, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Alternatively, the 1,3-thiazol-4-yl-glyoxyl ester is obtained by heating 17.1 g of 1,3-thiazol-4-yl-acetic acid ethyl ester in 50 ml of 1,2-dichloroethane together with 10.5 g of SeO2 with reflux on a water separator. When the separation of water is complete, the mixture is filtered with suction, the residue is washed with 1,2-dichloroethane, the combined dichloroethane phases are concentrated and the residue is distilled.

Workup

  1. customWhen the separation of water
  2. filtrationthe mixture is filtered with suction
  3. washthe residue is washed with 1,2-dichloroethane
  4. concentrationthe combined dichloroethane phases are concentrated
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-b9582bed11d04d15ab86b729fd7e044e
Source dataset
uspto-grants-1981_08
Patent number
US04282220

Reaction notes

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